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Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography

BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariquidar on the pharmacokinetics of P-gp substrate radiotracer (R)-[(11)C]verapamil in plasma and brain of rats and humans by means of positron emission tomography (PET). METHODS: Data obtained from a preclinical...

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Detalles Bibliográficos
Autores principales:	Müllauer, Julia, Kuntner, Claudia, Bauer, Martin, Bankstahl, Jens P, Müller, Markus, Voskuyl, Rob A, Langer, Oliver, Syvänen, Stina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520775/ https://www.ncbi.nlm.nih.gov/pubmed/23072492 http://dx.doi.org/10.1186/2191-219X-2-58

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