Cargando…

The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a calcium-dependent phosphatase, calcineurin. However, downstream effectors of C. neoformans calcineurin are largely unknown. In S. cerevisiae and other fungal species, a calcineurin-dependent transcription facto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lev, Sophie, Desmarini, Desmarini, Chayakulkeeree, Methee, Sorrell, Tania C., Djordjevic, Julianne T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520850/ https://www.ncbi.nlm.nih.gov/pubmed/23251520 http://dx.doi.org/10.1371/journal.pone.0051403

Ejemplares similares

Identification of Aph1, a Phosphate-Regulated, Secreted, and Vacuolar Acid Phosphatase in Cryptococcus neoformans
por: Lev, Sophie, et al.
Publicado: (2014)

Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans
por: Lev, Sophie, et al.
Publicado: (2020)

Identification of a major IP(5) kinase in Cryptococcus neoformans confirms that PP-IP(5)/IP(7), not IP(6), is essential for virulence
por: Li, Cecilia, et al.
Publicado: (2016)

Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Cryptococcus neoformans Present Novel Drug Targeting Opportunities
por: Lev, Sophie, et al.
Publicado: (2019)

The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency
por: Lev, Sophie, et al.
Publicado: (2019)

Calcium Binding Protein Ncs1 Is Calcineurin Regulated in Cryptococcus neoformans and Essential for Cell Division and Virulence
por: Squizani, Eamim Daidrê, et al.
Publicado: (2020)

Rapid Microscopy and Use of Vital Dyes: Potential to Determine Viability of Cryptococcus neoformans in the Clinical Laboratory
por: McMullan, Brendan J., et al.
Publicado: (2015)

Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans
por: Bowring, Bethany Grace, et al.
Publicado: (2023)

TNP Analogues Inhibit the Virulence Promoting IP(3-4) Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans
por: Desmarini, Desmarini, et al.
Publicado: (2022)

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH
por: Lev, Sophie, et al.
Publicado: (2017)

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
por: Chow, Eve W. L., et al.
Publicado: (2017)

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery
por: Li, Cecilia, et al.
Publicado: (2016)

Inositol polyphosphate–protein interactions: Implications for microbial pathogenicity
por: Lev, Sophie, et al.
Publicado: (2021)

Molecular Dissection of Crz1 and Its Dynamic Subcellular Localization in Cryptococcus neoformans
por: Chadwick, Benjamin J., et al.
Publicado: (2023)

Fungal Inositol Pyrophosphate IP(7) Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
por: Lev, Sophie, et al.
Publicado: (2015)

Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages
por: Hansakon, Adithap, et al.
Publicado: (2018)

Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation
por: Xu, Xinping, et al.
Publicado: (2017)

IP(7)-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
por: Desmarini, Desmarini, et al.
Publicado: (2020)

Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic Fungi
por: Yang, Yangyang, et al.
Publicado: (2022)

Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p
por: Polizotto, Renée S., et al.
Publicado: (2001)

Role of Phospholipases in Fungal Fitness, Pathogenicity, and Drug Development – Lessons from Cryptococcus Neoformans
por: Djordjevic, Julianne Teresa
Publicado: (2010)

Calcineurin-Responsive Transcription Factor CgCrzA Is Required for Cell Wall Integrity and Infection-Related Morphogenesis in Colletotrichum gloeosporioides
por: Wang, Ping, et al.
Publicado: (2020)

The Yeast Transcription Factor Crz1 Is Activated by Light in a Ca(2+)/Calcineurin-Dependent and PKA-Independent Manner
por: Bodvard, Kristofer, et al.
Publicado: (2013)

Pun1p is a metal ion-inducible, calcineurin/Crz1p-regulated plasma membrane protein required for cell wall integrity
por: Hosiner, Dagmar, et al.
Publicado: (2011)

RTA1 Is Involved in Resistance to 7-Aminocholesterol and Secretion of Fungal Proteins in Cryptococcus neoformans
por: Smith-Peavler, Emily S., et al.
Publicado: (2022)

Cryptococcus neoformans/gattii Species Complexes from Pre-HIV Pandemic Era Contain Unusually High Rate of Non-Wild-Type Isolates for Amphotericin B
por: Pharkjaksu, Sujiraphong, et al.
Publicado: (2020)

Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA
por: Soriani, Frederico M, et al.
Publicado: (2010)

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans
por: Jung, Won-Hee, et al.
Publicado: (2017)

Feline cutaneous nodular and ocular Cryptococcus neoformans in Belgium
por: Nunes Rodrigues, Tania C, et al.
Publicado: (2020)

etymologia: Cryptococcus neoformans
Publicado: (2008)

The capsule of Cryptococcus neoformans
por: Casadevall, Arturo, et al.
Publicado: (2018)

Triple infection with Cryptococcus, varicella-zoster virus, and Mycobacterium abscessus in a patient with anti-interferon-gamma autoantibodies: a case report
por: Rujirachun, Pongprueth, et al.
Publicado: (2020)

Transcriptional Regulation by Protein Kinase A in Cryptococcus neoformans
por: Hu, Guanggan, et al.
Publicado: (2007)

A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans
por: Paes, Hugo Costa, et al.
Publicado: (2018)

A glycosylated Phr1 protein is induced by calcium stress and its expression is positively controlled by the calcium/calcineurin signaling transcription factor Crz1 in Candida albicans
por: Jiang, Linghuo, et al.
Publicado: (2023)

Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii
por: Holcomb, Zachary E., et al.
Publicado: (2022)

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans
por: Morrow, Carl A., et al.
Publicado: (2012)

Puf4 Mediates Post-transcriptional Regulation of Cell Wall Biosynthesis and Caspofungin Resistance in Cryptococcus neoformans
por: Kalem, Murat C., et al.
Publicado: (2021)

Antifungal Peptide SP1 Damages Polysaccharide Capsule of Cryptococcus neoformans and Enhances Phagocytosis of Macrophages
por: Liu, Yan, et al.
Publicado: (2023)

Antifungal Susceptibilities of Cryptococcus neoformans
por: Archibald, Lennox K., et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_4iensg5r9kadqm3ck7m8o429do