Cargando…
Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Numerous p53 missense mutations possess gain-of-function activities. Studies in mouse models have demonstrated that the stabilization of p53 R172H (R175H in human) mutant protein, by currently unknown factors, is a prerequisite for its oncogenic gain-of-function phenotype such as tumour progression...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520893/ https://www.ncbi.nlm.nih.gov/pubmed/23251530 http://dx.doi.org/10.1371/journal.pone.0051426 |