ROS Production Is Essential for the Apoptotic Function of E2F1 in Pheochromocytoma and Neuroblastoma Cell Lines

In this study we demonstrate that accumulation of reactive oxygen species (ROS) is essential for E2F1 mediated apoptosis in ER-E2F1 PC12 pheochromocytoma, and SH-SY5Y and SK-N-JD neuroblastoma stable cell lines. In these cells, the ER-E2F1 fusion protein is expressed in the cytosol; the addition of...

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Detalles Bibliográficos
Autores principales: Espada, Lilia, Meo-Evoli, Nathalie, Sancho, Patricia, Real, Sebastian, Fabregat, Isabel, Ambrosio, Santiago, Tauler, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520901/
https://www.ncbi.nlm.nih.gov/pubmed/23251571
http://dx.doi.org/10.1371/journal.pone.0051544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520901/
https://www.ncbi.nlm.nih.gov/pubmed/23251571
http://dx.doi.org/10.1371/journal.pone.0051544

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