Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants

The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of KCNQ1 with an auxiliary KCNE1 subunit mediates a slowly activating current that accelerates the repolarization of action potential in cardiomyocytes. Mutations of KCNQ1 genes that result in reduction or loss...

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Detalles Bibliográficos
Autores principales: Zheng, Yueming, Zhu, Xuejing, Zhou, Pingzheng, Lan, Xi, Xu, Haiyan, Li, Min, Gao, Zhaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520906/
https://www.ncbi.nlm.nih.gov/pubmed/23251633
http://dx.doi.org/10.1371/journal.pone.0051820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520906/
https://www.ncbi.nlm.nih.gov/pubmed/23251633
http://dx.doi.org/10.1371/journal.pone.0051820

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