Mechanical Strain Downregulates C/EBPβ in MSC and Decreases Endoplasmic Reticulum Stress

Exercise prevents marrow mesenchymal stem cell (MSC) adipogenesis, reversing trends that accompany aging and osteoporosis. Mechanical input, the in-vitro analogue to exercise, limits PPARγ expression and adipogenesis in MSC. We considered whether C/EBPβ might be mechanoresponsive as it is upstream t...

Descripción completa

Detalles Bibliográficos
Autores principales: Styner, Maya, Meyer, Mark B., Galior, Kornelia, Case, Natasha, Xie, Zhihui, Sen, Buer, Thompson, William R., Pike, John Wesley, Rubin, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520924/
https://www.ncbi.nlm.nih.gov/pubmed/23251594
http://dx.doi.org/10.1371/journal.pone.0051613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520924/
https://www.ncbi.nlm.nih.gov/pubmed/23251594
http://dx.doi.org/10.1371/journal.pone.0051613

Ejemplares similares