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Mechanical Strain Downregulates C/EBPβ in MSC and Decreases Endoplasmic Reticulum Stress
Exercise prevents marrow mesenchymal stem cell (MSC) adipogenesis, reversing trends that accompany aging and osteoporosis. Mechanical input, the in-vitro analogue to exercise, limits PPARγ expression and adipogenesis in MSC. We considered whether C/EBPβ might be mechanoresponsive as it is upstream t...
Autores principales: | Styner, Maya, Meyer, Mark B., Galior, Kornelia, Case, Natasha, Xie, Zhihui, Sen, Buer, Thompson, William R., Pike, John Wesley, Rubin, Janet |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520924/ https://www.ncbi.nlm.nih.gov/pubmed/23251594 http://dx.doi.org/10.1371/journal.pone.0051613 |
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