Suppression of CB1 Cannabinoid Receptor by Lentivirus Mediated Small Interfering RNA Ameliorates Hepatic Fibrosis in Rats

It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering RNA (CB1-RNAi-LV) and investigated its effect...

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Detalles Bibliográficos
Autores principales: Chen, Si-Wen, Wu, Ben-Yan, Xu, Shi-Ping, Fan, Ke-Xing, Yan, Li, Gong, Yuan, Wen, Jun-Bao, Wu, Dao-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520929/
https://www.ncbi.nlm.nih.gov/pubmed/23251393
http://dx.doi.org/10.1371/journal.pone.0050850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520929/
https://www.ncbi.nlm.nih.gov/pubmed/23251393
http://dx.doi.org/10.1371/journal.pone.0050850

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