Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

The tripartite DENN module, comprised of a N-terminal longin domain, followed by DENN, and d-DENN domains, is a GDP-GTP exchange factor (GEFs) for Rab GTPases, which are regulators of practically all membrane trafficking events in eukaryotes. Using sequence and structure analysis we identify multipl...

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Detalles Bibliográficos
Autores principales: Zhang, Dapeng, Iyer, Lakshminarayan M., He, Fang, Aravind, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521125/
https://www.ncbi.nlm.nih.gov/pubmed/23248642
http://dx.doi.org/10.3389/fgene.2012.00283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521125/
https://www.ncbi.nlm.nih.gov/pubmed/23248642
http://dx.doi.org/10.3389/fgene.2012.00283

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