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Palindromic sequence impedes sequencing-by-ligation mechanism

BACKGROUND: Current next-generation sequencing (NGS) platforms adopt two types of sequencing mechanisms: by synthesis or by ligation. The former is employed by 454 and Solexa systems, while the latter by SOLiD system. Although the pros and cons for each sequencing mechanism have more or less been di...

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Detalles Bibliográficos
Autores principales: Huang, Yu-Feng, Chen, Sheng-Chung, Chiang, Yih-Shien, Chen, Tzu-Han, Chiu, Kuo-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521181/
https://www.ncbi.nlm.nih.gov/pubmed/23281822
http://dx.doi.org/10.1186/1752-0509-6-S2-S10