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Palindromic sequence impedes sequencing-by-ligation mechanism
BACKGROUND: Current next-generation sequencing (NGS) platforms adopt two types of sequencing mechanisms: by synthesis or by ligation. The former is employed by 454 and Solexa systems, while the latter by SOLiD system. Although the pros and cons for each sequencing mechanism have more or less been di...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521181/ https://www.ncbi.nlm.nih.gov/pubmed/23281822 http://dx.doi.org/10.1186/1752-0509-6-S2-S10 |