Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA. Protein arginine deiminase type 4 (PAD4) is the enzyme responsible for catalyzing the conversion of p...

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Detalles Bibliográficos
Autores principales: Teo, Chian Ying, Shave, Steven, Thean Chor, Adam Leow, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin Bin, Walkinshaw, Malcolm D, Tejo, Bimo A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521205/
https://www.ncbi.nlm.nih.gov/pubmed/23282142
http://dx.doi.org/10.1186/1471-2105-13-S17-S4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521205/
https://www.ncbi.nlm.nih.gov/pubmed/23282142
http://dx.doi.org/10.1186/1471-2105-13-S17-S4

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