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Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA. Protein arginine deiminase type 4 (PAD4) is the enzyme responsible for catalyzing the conversion of p...

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Detalles Bibliográficos
Autores principales:	Teo, Chian Ying, Shave, Steven, Thean Chor, Adam Leow, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin Bin, Walkinshaw, Malcolm D, Tejo, Bimo A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521205/ https://www.ncbi.nlm.nih.gov/pubmed/23282142 http://dx.doi.org/10.1186/1471-2105-13-S17-S4

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