Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors

The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites. This work presents a workflow for virtual screening and its application to Drug Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleo...

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Detalles Bibliográficos
Autores principales: ElHefnawi, Mahmoud, ElGamacy, Mohammad, Fares, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521232/
https://www.ncbi.nlm.nih.gov/pubmed/23282180
http://dx.doi.org/10.1186/1471-2105-13-S17-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521232/
https://www.ncbi.nlm.nih.gov/pubmed/23282180
http://dx.doi.org/10.1186/1471-2105-13-S17-S5

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