Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

Chromosomal DNA must be in single-strand form for important transactions such as replication, transcription, and recombination to occur. The single-strand DNA (ssDNA) is more prone to damage than double-strand DNA (dsDNA), due to greater exposure of chemically reactive moieties in the nitrogenous ba...

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Detalles Bibliográficos
Autores principales: Chan, Kin, Sterling, Joan F., Roberts, Steven A., Bhagwat, Ashok S., Resnick, Michael A., Gordenin, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521656/
https://www.ncbi.nlm.nih.gov/pubmed/23271983
http://dx.doi.org/10.1371/journal.pgen.1003149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521656/
https://www.ncbi.nlm.nih.gov/pubmed/23271983
http://dx.doi.org/10.1371/journal.pgen.1003149

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