Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

BACKGROUND: Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or cytoplasmatic microinjection into zygotes. Result...

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Detalles Bibliográficos
Autores principales: Zschemisch, Nils-Holger, Glage, Silke, Wedekind, Dirk, Weinstein, Edward J, Cui, Xiaoxia, Dorsch, Martina, Hedrich, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522011/
https://www.ncbi.nlm.nih.gov/pubmed/23136839
http://dx.doi.org/10.1186/1471-2172-13-60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522011/
https://www.ncbi.nlm.nih.gov/pubmed/23136839
http://dx.doi.org/10.1186/1471-2172-13-60

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