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Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

BACKGROUND: Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or cytoplasmatic microinjection into zygotes. Result...

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Detalles Bibliográficos
Autores principales:	Zschemisch, Nils-Holger, Glage, Silke, Wedekind, Dirk, Weinstein, Edward J, Cui, Xiaoxia, Dorsch, Martina, Hedrich, Hans-Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522011/ https://www.ncbi.nlm.nih.gov/pubmed/23136839 http://dx.doi.org/10.1186/1471-2172-13-60

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