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Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid
The PML-RARα fusion gene disrupts the retinoic acid differentiation signal in a range of leukaemia types, promoting proliferation. We designed a shRNA to target the fusion mRNA, and the shRNA expression cassette was delivered via lentiviral transduction. Delivery of this shRNA significantly down reg...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Journal of RNAi and Gene Silencing
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522483/ https://www.ncbi.nlm.nih.gov/pubmed/23300507 |