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Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid

The PML-RARα fusion gene disrupts the retinoic acid differentiation signal in a range of leukaemia types, promoting proliferation. We designed a shRNA to target the fusion mRNA, and the shRNA expression cassette was delivered via lentiviral transduction. Delivery of this shRNA significantly down reg...

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Detalles Bibliográficos
Autores principales:	Casey, Nicholas P, Woods, Gregory M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Journal of RNAi and Gene Silencing 2012
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522483/ https://www.ncbi.nlm.nih.gov/pubmed/23300507

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