IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse

BACKGROUND: IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (mdx) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is believed to contribute to the chronic inflammat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kostek, Matthew C, Nagaraju, Kanneboyina, Pistilli, Emidio, Sali, Arpana, Lai, San-Huei, Gordon, Brad, Chen, Yi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522537/
https://www.ncbi.nlm.nih.gov/pubmed/22716658
http://dx.doi.org/10.1186/1471-2474-13-106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522537/
https://www.ncbi.nlm.nih.gov/pubmed/22716658
http://dx.doi.org/10.1186/1471-2474-13-106

Ejemplares similares