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IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse

BACKGROUND: IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (mdx) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is believed to contribute to the chronic inflammat...

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Detalles Bibliográficos
Autores principales:	Kostek, Matthew C, Nagaraju, Kanneboyina, Pistilli, Emidio, Sali, Arpana, Lai, San-Huei, Gordon, Brad, Chen, Yi-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522537/ https://www.ncbi.nlm.nih.gov/pubmed/22716658 http://dx.doi.org/10.1186/1471-2474-13-106

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