Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples

BACKGROUND: DNA interstrand cross-links (ICLs) are critical lesions produced by several cancer chemotherapy agents including platinum drugs and nitrogen mustards. We have previously shown in haematological (multiple myeloma) and solid tumours (ovarian cancer) that clinical sensitivity to such agents...

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Detalles Bibliográficos
Autores principales: Spanswick, Victoria J, Lowe, Helen L, Newton, Claire, Bingham, John P, Bagnobianchi, Alessia, Kiakos, Konstantinos, Craddock, Charles, Ledermann, Jonathan A, Hochhauser, Daniel, Hartley, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522549/
https://www.ncbi.nlm.nih.gov/pubmed/23020514
http://dx.doi.org/10.1186/1471-2407-12-436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522549/
https://www.ncbi.nlm.nih.gov/pubmed/23020514
http://dx.doi.org/10.1186/1471-2407-12-436

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