Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

Identification of regulatable mechanisms by which transcription factor NF-E2 p45-related factor 2 (Nrf2) is repressed will allow strategies to be designed that counter drug resistance associated with its up-regulation in tumours that harbour somatic mutations in Kelch-like ECH-associated protein-1 (...

Descripción completa

Detalles Bibliográficos
Autores principales: Chowdhry, Sudhir, Zhang, Yiguo, McMahon, Michael, Sutherland, Calum, Cuadrado, Antonio, Hayes, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522573/
https://www.ncbi.nlm.nih.gov/pubmed/22964642
http://dx.doi.org/10.1038/onc.2012.388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522573/
https://www.ncbi.nlm.nih.gov/pubmed/22964642
http://dx.doi.org/10.1038/onc.2012.388

Ejemplares similares