The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli

Several neurodegenerative diseases are triggered by proteins containing a polyglutamine (polyQ) stretch expanded beyond a critical threshold. Among these, ataxin-3 (AT3) is the causative agent of spinocerebellar ataxia type-3. We expressed three authentic AT3 variants in Escherichia coli: one normal...

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Detalles Bibliográficos
Autores principales: Invernizzi, Gaetano, Aprile, Francesco A., Natalello, Antonino, Ghisleni, Andrea, Penco, Amanda, Relini, Annalisa, Doglia, Silvia M., Tortora, Paolo, Regonesi, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522584/
https://www.ncbi.nlm.nih.gov/pubmed/23251648
http://dx.doi.org/10.1371/journal.pone.0051890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522584/
https://www.ncbi.nlm.nih.gov/pubmed/23251648
http://dx.doi.org/10.1371/journal.pone.0051890

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