Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway

BACKGROUND: Oxygen free radicals induce lipid peroxidation (LPO) that damages and breaks polyunsaturated fatty acids in cell membranes. LPO-derived aldehydes and hydroxyalkenals react with DNA leading to the formation of etheno(ε)-bases including 1,N (6)-ethenoadenine (εA) and 3,N (4)-ethenocytosine...

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Detalles Bibliográficos
Autores principales: Prorok, Paulina, Saint-Pierre, Christine, Gasparutto, Didier, Fedorova, Olga S., Ishchenko, Alexander A., Leh, Hervé, Buckle, Malcolm, Tudek, Barbara, Saparbaev, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522590/
https://www.ncbi.nlm.nih.gov/pubmed/23251620
http://dx.doi.org/10.1371/journal.pone.0051776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522590/
https://www.ncbi.nlm.nih.gov/pubmed/23251620
http://dx.doi.org/10.1371/journal.pone.0051776

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