Ustekinumab Improves Psoriasis without Altering T Cell Cytokine Production, Differentiation, and T Cell Receptor Repertoire Diversity

Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 subunit. The role of IL-12/23-mediated pathway in the mechanism of various inflammatory disorders especially psoriasis has been well recognized. Recently the long-term efficacy and safety of ustekinumab in pa...

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Detalles Bibliográficos
Autores principales: Tsuda, Kenshiro, Yamanaka, Keiichi, Kondo, Makoto, Matsubara, Kimiko, Sasaki, Ryogen, Tomimoto, Hidekazu, Gabazza, Esteban C., Mizutani, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522598/
https://www.ncbi.nlm.nih.gov/pubmed/23251632
http://dx.doi.org/10.1371/journal.pone.0051819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522598/
https://www.ncbi.nlm.nih.gov/pubmed/23251632
http://dx.doi.org/10.1371/journal.pone.0051819

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