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4F Decreases IRF5 Expression and Activation in Hearts of Tight Skin Mice
The apoAI mimetic 4F was designed to inhibit atherosclerosis by improving HDL. We reported that treating tight skin (Tsk(−/+)) mice, a model of systemic sclerosis (SSc), with 4F decreases inflammation and restores angiogenic potential in Tsk(−/+) hearts. Interferon regulating factor 5 (IRF5) is impo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522636/ https://www.ncbi.nlm.nih.gov/pubmed/23251680 http://dx.doi.org/10.1371/journal.pone.0052046 |