A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations

The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disorders in the world, which results in quantitative defects of the glo...

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Detalles Bibliográficos
Autores principales: Papadopoulos, Petros, Gutiérrez, Laura, van der Linden, Reinier, Kong-A-San, John, Maas, Alex, Drabek, Dubravka, Patrinos, George P., Philipsen, Sjaak, Grosveld, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522686/
https://www.ncbi.nlm.nih.gov/pubmed/23272095
http://dx.doi.org/10.1371/journal.pone.0051272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522686/
https://www.ncbi.nlm.nih.gov/pubmed/23272095
http://dx.doi.org/10.1371/journal.pone.0051272

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