Receptor-Recognized α(2)-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells

OBJECTIVE: Tetrameric α(2)-macroglobulin (α(2)M), a plasma panproteinase inhibitor, is activated upon interaction with a proteinase, and undergoes a major conformational change exposing a receptor recognition site in each of its subunits. Activated α(2)M (α(2)M*) binds to cancer cell surface GRP78 a...

Descripción completa

Detalles Bibliográficos
Autores principales: Misra, Uma K., Pizzo, Salvatore V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522726/
https://www.ncbi.nlm.nih.gov/pubmed/23272152
http://dx.doi.org/10.1371/journal.pone.0051735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522726/
https://www.ncbi.nlm.nih.gov/pubmed/23272152
http://dx.doi.org/10.1371/journal.pone.0051735

Ejemplares similares