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Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2
Recently we employed phylogenetics to predict that the cellular interpretation of TGF-β signals is modulated by monoubiquitylation cycles affecting the Smad4 signal transducer/tumor suppressor. This prediction was subsequently validated by experiments in flies, frogs and mammalian cells. Here we app...
Autores principales: | Wisotzkey, Robert G., Konikoff, Charlotte E., Newfeld, Stuart J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522738/ https://www.ncbi.nlm.nih.gov/pubmed/23272121 http://dx.doi.org/10.1371/journal.pone.0051599 |
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