Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection, and neurogenesis in laboratory animals, and has entered phase II clinical trials for both Alzheimer’s (AD) and Huntington’s diseases (HD). Based on recent indications that latrep...

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Detalles Bibliográficos
Autores principales: Steele, John W., Ju, Shulin, Lachenmayer, M. Lenard, Liken, Jessica, Stock, Aryeh, Kim, Soong Ho, Delgado, Luz M., Alfaro, Iván E, Bernales, Sebastian, Verdile, Giuseppe, Bharadwaj, Prashant, Gupta, Veer, Barr, Renae, Friss, Amy, Dolios, Georgia, Wang, Rong, Ringe, Dagmar, Protter, Andrew A., Martins, Ralph N., Ehrlich, Michelle E., Yue, Zhenyu, Petsko, Gregory A., Gandy, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523214/
https://www.ncbi.nlm.nih.gov/pubmed/22869031
http://dx.doi.org/10.1038/mp.2012.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523214/
https://www.ncbi.nlm.nih.gov/pubmed/22869031
http://dx.doi.org/10.1038/mp.2012.115

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