The Role of the Cullin-5 E3 Ubiquitin Ligase in the Regulation of Insulin Receptor Substrate-1

Background. SOCS proteins are known to negatively regulate insulin signaling by inhibiting insulin receptor substrate-1 (IRS1). IRS1 has been reported to be a substrate for ubiquitin-dependent proteasomal degradation. Given that SOCS proteins can function as substrate receptor subunits of Cullin-5 E...

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Detalles Bibliográficos
Autores principales: Hu, Christine Zhiwen, Sethi, Jaswinder K., Hagen, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523409/
https://www.ncbi.nlm.nih.gov/pubmed/23304509
http://dx.doi.org/10.1155/2012/282648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523409/
https://www.ncbi.nlm.nih.gov/pubmed/23304509
http://dx.doi.org/10.1155/2012/282648

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