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Guanidine-HCl Dependent Structural Unfolding of M-Crystallin: Fluctuating Native State Like Topologies and Intermolecular Association

Numerous experimental techniques and computational studies, proposed in recent times, have revolutionized the understanding of protein-folding paradigm. The complete understanding of protein folding and intermediates are of medical relevance, as the aggregation of misfolding proteins underlies vario...

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Detalles Bibliográficos
Autores principales: Barnwal, Ravi Pratap, Agarwal, Geetika, Chary, Kandala V. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524170/
https://www.ncbi.nlm.nih.gov/pubmed/23284604
http://dx.doi.org/10.1371/journal.pone.0042948