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Expression and Activity of Fyn Mediate Proliferation and Blastic Features of Chronic Myelogenous Leukemia
The BCR-ABL1 oncogene is a tyrosine kinase that activates many signaling pathways, resulting in the induction of chronic myeloid leukemia (CML). Kinase inhibitors, such as imatinib, have been developed for the treatment of CML; however, the terminal, blast crisis phase of the disease remains a clini...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524192/ https://www.ncbi.nlm.nih.gov/pubmed/23284724 http://dx.doi.org/10.1371/journal.pone.0051611 |