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Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs in different cancer types and is linked with drug resistance to cancer therapies. It is well known that Mcl-1 pre-mRNA undergoes alternative splicing events to produce two functionally distinct proteins, Mcl-1(S) (...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524227/ https://www.ncbi.nlm.nih.gov/pubmed/23284704 http://dx.doi.org/10.1371/journal.pone.0051497 |