Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy

MicroRNAs (miRNAs) are key regulators of sequence-specific gene silencing. However, crucial factors that determine the efficacy of miRNA-mediated target gene silencing are poorly understood. Here we mathematized base-pairing stability and showed that miRNAs with an unstable 5′ terminal duplex and st...

Descripción completa

Detalles Bibliográficos
Autores principales: Hibio, Naoki, Hino, Kimihiro, Shimizu, Eigo, Nagata, Yoshiro, Ui-Tei, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524778/
https://www.ncbi.nlm.nih.gov/pubmed/23251782
http://dx.doi.org/10.1038/srep00996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524778/
https://www.ncbi.nlm.nih.gov/pubmed/23251782
http://dx.doi.org/10.1038/srep00996

Ejemplares similares