DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein kinase (DNA-PK) as a DNA sensor that activates innate immunity. We show that DNA-PK acts as a patte...

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Detalles Bibliográficos
Autores principales: Ferguson, Brian J, Mansur, Daniel S, Peters, Nicholas E, Ren, Hongwei, Smith, Geoffrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524801/
https://www.ncbi.nlm.nih.gov/pubmed/23251783
http://dx.doi.org/10.7554/eLife.00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524801/
https://www.ncbi.nlm.nih.gov/pubmed/23251783
http://dx.doi.org/10.7554/eLife.00047

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