Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner

Epigenetic silencing of gene expression is important in cancer. Aberrant DNA CpG island hypermethylation and histone modifications are involved in the aberrant silencing of tumour-suppressor genes. LSD1 (lysine-specific demethylase 1) is a H3K4 (histone H3 Lys(4)) demethylase associated with gene re...

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Detalles Bibliográficos
Autores principales: Jin, Lihua, Hanigan, Christin L., Wu, Yu, Wang, Wei, Park, Ben Ho, Woster, Patrick M., Casero, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525012/
https://www.ncbi.nlm.nih.gov/pubmed/23072722
http://dx.doi.org/10.1042/BJ20121360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525012/
https://www.ncbi.nlm.nih.gov/pubmed/23072722
http://dx.doi.org/10.1042/BJ20121360

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