Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

Members of the NR1I subfamily of nuclear receptors play a role in the transcriptional activation of genes involved in drug metabolism and transport. NR1I3, the constitutive androstane receptor (CAR), mediates the induction of several genes involved in drug response, including members of the CYP3A, C...

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Detalles Bibliográficos
Autores principales: Thompson, Emma E, Kuttab-Boulos, Hala, Krasowski, Matthew D, Di Rienzo, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525124/
https://www.ncbi.nlm.nih.gov/pubmed/16197734
http://dx.doi.org/10.1186/1479-7364-2-3-168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525124/
https://www.ncbi.nlm.nih.gov/pubmed/16197734
http://dx.doi.org/10.1186/1479-7364-2-3-168

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