Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity–onset diabetes of the young type II (MODY-II) and persistent hypogl...

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Detalles Bibliográficos
Autores principales: Larion, Mioara, Salinas, Roberto Kopke, Bruschweiler-Li, Lei, Miller, Brian G., Brüschweiler, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525530/
https://www.ncbi.nlm.nih.gov/pubmed/23271955
http://dx.doi.org/10.1371/journal.pbio.1001452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525530/
https://www.ncbi.nlm.nih.gov/pubmed/23271955
http://dx.doi.org/10.1371/journal.pbio.1001452

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