Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

Lysosomal enzymes function optimally in acidic environments, and elevation of lysosomal pH can impede their ability to degrade material delivered to lysosomes through autophagy or phagocytosis. We hypothesize that abnormal lysosomal pH is a key aspect in diseases of accumulation and that restoring l...

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Detalles Bibliográficos
Autores principales: Baltazar, Gabriel C., Guha, Sonia, Lu, Wennan, Lim, Jason, Boesze-Battaglia, Kathleen, Laties, Alan M., Tyagi, Puneet, Kompella, Uday B., Mitchell, Claire H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525582/
https://www.ncbi.nlm.nih.gov/pubmed/23272048
http://dx.doi.org/10.1371/journal.pone.0049635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525582/
https://www.ncbi.nlm.nih.gov/pubmed/23272048
http://dx.doi.org/10.1371/journal.pone.0049635

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