β-Catenin Directly Sequesters Adipocytic and Insulin Sensitizing Activities but Not Osteoblastic Activity of PPARγ2 in Marrow Mesenchymal Stem Cells

Lineage allocation of the marrow mesenchymal stem cells (MSCs) to osteoblasts and adipocytes is dependent on both Wnt signaling and PPARγ2 activity. Activation of PPARγ2, an essential regulator of energy metabolism and insulin sensitivity, stimulates adipocyte and suppresses osteoblast differentiati...

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Detalles Bibliográficos
Autores principales: Rahman, Sima, Czernik, Piotr J., Lu, Yalin, Lecka-Czernik, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525589/
https://www.ncbi.nlm.nih.gov/pubmed/23272157
http://dx.doi.org/10.1371/journal.pone.0051746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525589/
https://www.ncbi.nlm.nih.gov/pubmed/23272157
http://dx.doi.org/10.1371/journal.pone.0051746

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