Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors

Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure i...

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Autores principales: Amaddeo, Giuliana, Guichard, Cécile, Imbeaud, Sandrine, Zucman-Rossi, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525620/
https://www.ncbi.nlm.nih.gov/pubmed/23264911
http://dx.doi.org/10.4161/onci.21480
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author Amaddeo, Giuliana
Guichard, Cécile
Imbeaud, Sandrine
Zucman-Rossi, Jessica
author_facet Amaddeo, Giuliana
Guichard, Cécile
Imbeaud, Sandrine
Zucman-Rossi, Jessica
author_sort Amaddeo, Giuliana
collection PubMed
description Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure in the etiology of HCC, which remains to be characterized.
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spelling pubmed-35256202012-12-21 Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors Amaddeo, Giuliana Guichard, Cécile Imbeaud, Sandrine Zucman-Rossi, Jessica Oncoimmunology Author's View Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure in the etiology of HCC, which remains to be characterized. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525620/ /pubmed/23264911 http://dx.doi.org/10.4161/onci.21480 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Amaddeo, Giuliana
Guichard, Cécile
Imbeaud, Sandrine
Zucman-Rossi, Jessica
Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title_full Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title_fullStr Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title_full_unstemmed Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title_short Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
title_sort next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525620/
https://www.ncbi.nlm.nih.gov/pubmed/23264911
http://dx.doi.org/10.4161/onci.21480
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