Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma

Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the growing list of immune defects of multiple myeloma patients. The increasing complexity of the cancer-associated immune defects must be attent...

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Autores principales: Brown, Ross, Suen, Hayley, Favaloro, James, Yang, Shihong, Ho, P. Joy, Gibson, John, Joshua, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525637/
https://www.ncbi.nlm.nih.gov/pubmed/23264928
http://dx.doi.org/10.4161/onci.22032
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author Brown, Ross
Suen, Hayley
Favaloro, James
Yang, Shihong
Ho, P. Joy
Gibson, John
Joshua, Douglas
author_facet Brown, Ross
Suen, Hayley
Favaloro, James
Yang, Shihong
Ho, P. Joy
Gibson, John
Joshua, Douglas
author_sort Brown, Ross
collection PubMed
description Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the growing list of immune defects of multiple myeloma patients. The increasing complexity of the cancer-associated immune defects must be attentively considered for attempting to improve the so-far unsatisfactory rates of clinical responses to immunotherapy in patients affected by multiple myeloma and other malignancies.
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spelling pubmed-35256372012-12-21 Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma Brown, Ross Suen, Hayley Favaloro, James Yang, Shihong Ho, P. Joy Gibson, John Joshua, Douglas Oncoimmunology Author's View Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the growing list of immune defects of multiple myeloma patients. The increasing complexity of the cancer-associated immune defects must be attentively considered for attempting to improve the so-far unsatisfactory rates of clinical responses to immunotherapy in patients affected by multiple myeloma and other malignancies. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525637/ /pubmed/23264928 http://dx.doi.org/10.4161/onci.22032 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Brown, Ross
Suen, Hayley
Favaloro, James
Yang, Shihong
Ho, P. Joy
Gibson, John
Joshua, Douglas
Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title_full Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title_fullStr Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title_full_unstemmed Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title_short Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
title_sort trogocytosis generates acquired regulatory t cells adding further complexity to the dysfunctional immune response in multiple myeloma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525637/
https://www.ncbi.nlm.nih.gov/pubmed/23264928
http://dx.doi.org/10.4161/onci.22032
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