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Viral Dose, Radioiodine Uptake, and Delayed Efflux in Adenovirus Mediated NIS Radiovirotherapy Correlates with Treatment Efficacy
We have constructed a prostate tumor specific conditionally replicating adenovirus (CRAd), named Ad5PB_RSV-NIS that expresses the human sodium iodine symporter gene (hNIS). LNCaP tumors were established in nude mice and infected with this CRAd to study tumor viral spread, NIS expression, and efficac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525803/ https://www.ncbi.nlm.nih.gov/pubmed/22972493 http://dx.doi.org/10.1038/gt.2012.71 |