Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory....

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Autores principales: Russ, Brendan E., Denton, Alice E., Hatton, Lauren, Croom, Hayley, Olson, Matthew R., Turner, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525900/
https://www.ncbi.nlm.nih.gov/pubmed/23267358
http://dx.doi.org/10.3389/fimmu.2012.00371
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author Russ, Brendan E.
Denton, Alice E.
Hatton, Lauren
Croom, Hayley
Olson, Matthew R.
Turner, Stephen J.
author_facet Russ, Brendan E.
Denton, Alice E.
Hatton, Lauren
Croom, Hayley
Olson, Matthew R.
Turner, Stephen J.
author_sort Russ, Brendan E.
collection PubMed
description A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.
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spelling pubmed-35259002012-12-24 Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection Russ, Brendan E. Denton, Alice E. Hatton, Lauren Croom, Hayley Olson, Matthew R. Turner, Stephen J. Front Immunol Immunology A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity. Frontiers Media S.A. 2012-12-19 /pmc/articles/PMC3525900/ /pubmed/23267358 http://dx.doi.org/10.3389/fimmu.2012.00371 Text en Copyright © Russ, Denton, Hatton, Croom, Olson and Turner. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Russ, Brendan E.
Denton, Alice E.
Hatton, Lauren
Croom, Hayley
Olson, Matthew R.
Turner, Stephen J.
Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title_full Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title_fullStr Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title_full_unstemmed Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title_short Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
title_sort defining the molecular blueprint that drives cd8(+) t cell differentiation in response to infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525900/
https://www.ncbi.nlm.nih.gov/pubmed/23267358
http://dx.doi.org/10.3389/fimmu.2012.00371
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