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Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells

B-cell lymphoma 2 (Bcl-2) family proteins are established regulators of cell survival, but their involvement in the normal function of primary cells has only recently begun to receive attention. In this study, we demonstrate that chemical and genetic loss-of-function of antiapoptotic Bcl-2 and Bcl-x...

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Detalles Bibliográficos
Autores principales: Luciani, Dan S., White, Sarah A., Widenmaier, Scott B., Saran, Varun V., Taghizadeh, Farnaz, Hu, Xiaoke, Allard, Michael F., Johnson, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526034/
https://www.ncbi.nlm.nih.gov/pubmed/22933114
http://dx.doi.org/10.2337/db11-1464