Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation

Gene downregulation by antisense morpholino oligonucleotides (MOs) is achieved by either hybridization around the translation initiation codon or by targeting the splice donor site. In the present study, an antisense MO method is introduced that uses a 25-mer MO against a region at least 40-nt upstr...

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Detalles Bibliográficos
Autores principales: Wada, Tadashi, Hara, Masatoshi, Taneda, Takuya, Qingfu, Cao, Takata, Ryouhei, Moro, Kanako, Takeda, Kei, Kishimoto, Takeo, Handa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526265/
https://www.ncbi.nlm.nih.gov/pubmed/22904086
http://dx.doi.org/10.1093/nar/gks765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526265/
https://www.ncbi.nlm.nih.gov/pubmed/22904086
http://dx.doi.org/10.1093/nar/gks765

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