A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network

The epigenetic changes during B-cell development relevant to both normal function and hematologic malignancy are incompletely understood. We examined DNA methylation and RNA expression status during early B-cell development by sorting multiple replicates of four separate stages of pre-B cells derive...

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Detalles Bibliográficos
Autores principales: Lee, Seung-Tae, Xiao, Yuanyuan, Muench, Marcus O., Xiao, Jianqiao, Fomin, Marina E., Wiencke, John K., Zheng, Shichun, Dou, Xiaoqin, de Smith, Adam, Chokkalingam, Anand, Buffler, Patricia, Ma, Xiaomei, Wiemels, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526268/
https://www.ncbi.nlm.nih.gov/pubmed/23074194
http://dx.doi.org/10.1093/nar/gks957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526268/
https://www.ncbi.nlm.nih.gov/pubmed/23074194
http://dx.doi.org/10.1093/nar/gks957

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