Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage

DNA-binding and modifying proteins show high specificity but also exhibit a certain level of promiscuity. Such latent promiscuous activities comprise the starting points for new protein functions, but this hypothesis presents a paradox: a new activity can only evolve if it already exists. How then,...

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Detalles Bibliográficos
Autores principales: Rockah-Shmuel, Liat, Tawfik, Dan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526282/
https://www.ncbi.nlm.nih.gov/pubmed/23074188
http://dx.doi.org/10.1093/nar/gks944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526282/
https://www.ncbi.nlm.nih.gov/pubmed/23074188
http://dx.doi.org/10.1093/nar/gks944

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