Cargando…

DNA-binding determinants promoting NHEJ by human Polµ

Non-homologous end-joining (NHEJ), the preferred pathway to repair double-strand breaks (DSBs) in higher eukaryotes, relies on a collection of molecular tools to process the broken ends, including specific DNA polymerases. Among them, Polµ is unique as it can catalyze DNA synthesis upon connection o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Maria Jose, Juarez, Raquel, Blanco, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526283/ https://www.ncbi.nlm.nih.gov/pubmed/23034807 http://dx.doi.org/10.1093/nar/gks896

Ejemplares similares

DNA expansions generated by human Polµ on iterative sequences
por: Aza, Ana, et al.
Publicado: (2013)

DNA-PK(cs)-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
por: Lu, Huiming, et al.
Publicado: (2022)

Polμ tumor variants decrease the efficiency and accuracy of NHEJ
por: Sastre-Moreno, Guillermo, et al.
Publicado: (2017)

Stress-inducible NHEJ in bacteria: function in DNA repair and acquisition of heterologous DNA
por: Dupuy, Pierre, et al.
Publicado: (2019)

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
por: Britton, Sébastien, et al.
Publicado: (2020)

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein
por: Morin, José A., et al.
Publicado: (2017)

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ
por: Schellenbauer, Amelie, et al.
Publicado: (2021)

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
por: Kefala Stavridi, Antonia, et al.
Publicado: (2023)

RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’
por: Gigi, Vered, et al.
Publicado: (2014)

Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
por: Fu, Ya-Wen, et al.
Publicado: (2021)

A new assay capturing chromosome fusions shows a protection trade-off at telomeres and NHEJ vulnerability to low-density ionizing radiation
por: Pobiega, Sabrina, et al.
Publicado: (2021)

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation
por: Wang, Hongyan, et al.
Publicado: (2010)

Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains
por: Sebesta, Marek, et al.
Publicado: (2017)

The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis
por: Zhang, Xin, et al.
Publicado: (2016)

Lesion-specific DNA-binding and repair activities of human O(6)-alkylguanine DNA alkyltransferase
por: Melikishvili, Manana, et al.
Publicado: (2012)

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding
por: Szambowska, Anna, et al.
Publicado: (2014)

Acetylation-dependent function of human single-stranded DNA binding protein 1
por: Wu, Yuanzhong, et al.
Publicado: (2015)

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
por: Fatoba, Samuel T., et al.
Publicado: (2013)

The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
por: Chojnacki, Michaelle, et al.
Publicado: (2018)

Mapping DNA conformations and interactions within the binding cleft of bacteriophage T4 single-stranded DNA binding protein (gp32) at single nucleotide resolution
por: Camel, Benjamin R, et al.
Publicado: (2020)

The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
por: Keller, Heidi, et al.
Publicado: (2014)

Mapping the interactions of the single-stranded DNA binding protein of bacteriophage T4 (gp32) with DNA lattices at single nucleotide resolution: polynucleotide binding and cooperativity
por: Jose, Davis, et al.
Publicado: (2015)

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein
por: Kaur, Parminder, et al.
Publicado: (2018)

Mapping the interactions of the single-stranded DNA binding protein of bacteriophage T4 (gp32) with DNA lattices at single nucleotide resolution: gp32 monomer binding
por: Jose, Davis, et al.
Publicado: (2015)

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells
por: Di Re, M., et al.
Publicado: (2009)

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA
por: Woodcock, Clayton B, et al.
Publicado: (2020)

Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein
por: Sharadamma, N., et al.
Publicado: (2010)

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1
por: Colombo, Chiara Vittoria, et al.
Publicado: (2017)

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing
por: Kanter, Diane M., et al.
Publicado: (2011)

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes
por: Grimme, Jill M., et al.
Publicado: (2010)

Single-molecule FRET studies of the cooperative and non-cooperative binding kinetics of the bacteriophage T4 single-stranded DNA binding protein (gp32) to ssDNA lattices at replication fork junctions
por: Lee, Wonbae, et al.
Publicado: (2016)

Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation
por: Guilbaud, Guillaume, et al.
Publicado: (2022)

DnaC traps DnaB as an open ring and remodels the domain that binds primase
por: Chodavarapu, Sundari, et al.
Publicado: (2016)

MutL binds to 3′ resected DNA ends and blocks DNA polymerase access
por: Borsellini, Alessandro, et al.
Publicado: (2022)

The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein
por: Naue, Natalie, et al.
Publicado: (2013)

An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase
por: Windgassen, Tricia A., et al.
Publicado: (2016)

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions
por: Weiser, Brian P, et al.
Publicado: (2018)

Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA
por: Furukohri, Asako, et al.
Publicado: (2012)

Dynamic binding of replication protein a is required for DNA repair
por: Chen, Ran, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_plgqsfjqctsaiothk7q8hft1fi